A recent report indicates that topical non-steroidal anti-inflammatory drugs (NSAISs) may be safe and effective for acute musculoskeletal conditions in adults.
The use of topical NSAIDs is attractive because there is found to be no GI side effects from using these medications compared to taking the same medications by mouth.
The goal of the study was to evaluate the evidence from randomized double blind, controlled trials of the efficacy and safety of topically applied NSAIDs for relief of acute pain. There were very few systemic adverse events or adverse events causing study withdrawals, and local skin reactions were usually mild, self-limited, and not different from those seen with placebo.
It has been concluded that topical NSAIDs can provide good levels of pain relief without the systemic adverse events associated with oral NSAIDs when used to treat acute musculoskeletal conditions.
Topical NSAIDs can provide good levels of pain relief in acute conditions such as sprains, strains and overuse injuries, probably similar to that provided by oral NSAIDs. Topical NSAIDs are not associated with an increased incidence of local skin reactions compared with placebo, and do not cause systemic(gastrointestinal problems) problems seen with oral NSAIDs. This makes them particularly useful for individuals unable to tolerate taking these medications by mouth.
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